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Projects / Programmes
Bioaktivne snovi iz nižjih vodnih organizmov in njihov mehanizem delovanja (Slovene)
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 1.05.00 | Natural sciences and mathematics | Biochemistry and molecular biology |
| Code | Science | Field |
|---|---|---|
| P310 | Natural sciences and mathematics | Proteins, enzymology |
| P340 | Natural sciences and mathematics | Lipids, steroids, membranes |
Keywords
Cianobacteria, cnidaria, sea anemone, marine sponge, microcystin, toxin, pore-forming toxin, cytolysin, alkylpyridinium polymer, anticholinesterase, inhibitor, lipid membrane, hemolysis, cytotoxicity.
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (3) , Researchers (11)
0487 Biotechnical Faculty, Department ob Biology
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 15686 | Biochemistry and molecular biology | Researcher | 1998 - 2001 | 1,009 | |
| 2. | 06994 | Biochemistry and molecular biology | Head | 2000 - 2001 | 538 | |
| 3. | 18203 | Cardiovascular system | Researcher | 1996 - 2001 | 44 | |
| 4. | 17422 | Researcher | 2000 - 2001 | 3 | ||
| 5. | 06902 | Biochemistry and molecular biology | Researcher | 2000 - 2001 | 138 | |
| 6. | 12278 | Microbiology and immunology | Researcher | 1996 - 2001 | 717 | |
| 7. | 15328 | Biochemistry and molecular biology | Researcher | 1999 - 2001 | 774 | |
| 8. | 06905 | Biochemistry and molecular biology | Researcher | 2000 - 2001 | 651 |
0105 National Institute of Biology
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 07736 | Biochemistry and molecular biology | Researcher | 1996 - 2001 | 253 |
0106 Jožef Stefan Institute
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 01115 | Physics | Researcher | 1996 - 2001 | 364 | |
| 2. | 11035 | Physics | Researcher | 1996 - 2001 | 369 |
Abstract
Fresh and sea water organisms (cianobacteria, coelenterates, marine sponges) are screened for toxins using bio-assays, and cholinesterase inhibitors employing enzyme tests. In fresh water cianobacterial blooms, microcystins are determined and their levels correlated to ecological factors and abundance of photosynthetic algae. Mechanism of action of a wild-type and recombinant proteinaceous pore-forming toxin from the sea anemone Actinia equina and its mutants are studied using cells and artificial lipid membranes. Topology and kinetics of the toxin binding, insertion and pore formation are studied. Surface active and anticholinesterase compounds are isolated from marine sponges. Mechanism of anticholinesterase activity of 3-alkylpyridinium polymers isolated from the marine sponge Reniera sarai is studied using recombinant insect acetylcholinesterase. Their surfactant-like activity, e.g. hemolysis, is characterized as compared to that of low molecular surfactants.