Loading...
Projects / Programmes
Regulation of gene expression by steroids in primitive eucaryots and the application of P450 gene technology in medicine
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 1.05.00 | Natural sciences and mathematics | Biochemistry and molecular biology |
| Code | Science | Field |
|---|---|---|
| P004 | Natural sciences and mathematics | Biochemistry, Metabolism |
| P320 | Natural sciences and mathematics | Nucleic acids, protein synthesis |
Keywords
cytochrome P450, regulation, filamentous fungi, receptors, gene polymorphism, human cancer
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (3) , Researchers (9)
0302 Institute of Oncology Ljubljana
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 08750 | Oncology | Researcher | 1996 - 2001 | 258 |
0312 University Medical Centre Ljubljana
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 01989 | Metabolic and hormonal disorders | Researcher | 1996 - 2001 | 303 |
0381 University of Ljubljana, Faculty of Medicine
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 03079 | Biochemistry and molecular biology | Head | 1999 - 2001 | 190 | |
| 2. | 08777 | Biochemistry and molecular biology | Researcher | 1998 - 2001 | 98 | |
| 3. | 11711 | Biochemistry and molecular biology | Researcher | 1998 - 2001 | 812 | |
| 4. | 18847 | Researcher | 2000 - 2001 | 0 | ||
| 5. | 02934 | Biochemistry and molecular biology | Researcher | 1996 - 2001 | 78 | |
| 6. | 07085 | Biochemistry and molecular biology | Researcher | 1999 - 2001 | 50 | |
| 7. | 07086 | Researcher | 1999 - 2001 | 5 |
Abstract
a. In filamentous fungi steroids induce various enzymes and enzyme systems. The mechanisms of gene expression regulation was studies on three different levels: on receptor level, on cAMP level and on gene level. Steroid inducible enzymes of hydroxylase systems were also studied. b. There are two important aspects of P450 enzymes in human metabolism: one is metabolism of endogenous substances like steroids and the other is metabolism of xenobiotics such as drugs and carcinogens. Mutations in CYP21 gene (steroid 21-hydroxylase) were studied in slovenian patients with polycystic ovary syndrom. Genetic polymorphism of CYP1A1 (aryl-hydrocarbon hydroxylase) was studied in order to evaluate susceptibility to lung cancer.