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Projects / Programmes
Tissue receptors for phospholipases A2 from snake venoms
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 1.05.00 | Natural sciences and mathematics | Biochemistry and molecular biology |
| Code | Science | Field |
|---|---|---|
| P310 | Natural sciences and mathematics | Proteins, enzymology |
| P340 | Natural sciences and mathematics | Lipids, steroids, membranes |
Keywords
phospholipase A2, neurotoxin, synapse, receptor, neurotransmitter
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (1) , Researchers (6)
0106 Jožef Stefan Institute
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 01088 | Biochemistry and molecular biology | Researcher | 1999 - 2001 | 47 | |
| 2. | 01083 | Biochemistry and molecular biology | Researcher | 1998 - 2001 | 559 | |
| 3. | 00412 | Biochemistry and molecular biology | Head | 1998 - 2001 | 758 | |
| 4. | 18802 | Biochemistry and molecular biology | Researcher | 1999 - 2001 | 170 | |
| 5. | 11058 | Biochemistry and molecular biology | Researcher | 1998 - 2001 | 22 | |
| 6. | 04570 | Biochemistry and molecular biology | Researcher | 1998 - 2001 | 331 |
Abstract
Certain phospholipases A2 have evolved different pharmacological activities during evolution. In the proposed project we plan to investigate tissue receptors for presynaptically neurotoxic phospholipases A2. The main goal of the project is to isolate the neuronal receptor of ammodytoxins, neurotoxic phospholipases A2 from the long-nosed viper venom. This research will contribute to understanding the mechanism of action of ammodytoxins and to their potential use as specific ligands in neurobiology and medicine.