Projects / Programmes source: ARIS

Spectroscopic investigation of cationic lipids structure and their complexes with DNA

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Research activity

Code Science Field Subfield
1.04.02  Natural sciences and mathematics  Chemistry  Structural chemistry 

Code Science Field
P351  Natural sciences and mathematics  Structure chemistry 
Keywords
infrared, raman, NMR, structure of cationic amphiphiles, DNA interaction, model calculations
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source: COBISS
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Organisations (1) , Researchers (3)
0104  National Institute of Chemistry
no. Code Name and surname Research area Role Period No. of publications
1.  08523  PhD Jože Grdadolnik  Chemistry  Head  1999 - 2001  269 
2.  08611  PhD Janez Mavri  Chemistry  Researcher  1998 - 2001  377 
3.  12060  PhD Primož Pristovšek  Chemistry  Researcher  1998 - 2001  135 
Abstract
Cationic lipid-DNA complex will be studied by vibrational and NMR spectroscopy and theoretical calculations on model compounds. The investigation will include variation in the type of cationic amphiphiles (different polar head groups) mixed with helper lipid, DNA mimics and DNA molecules. The spectroscopic studies will focuse on both structural changes (mainly changes in the conformation of polar head groups) and changes in mobility of amphiphilic molecules due to complex formation with DNA and DNA mimics.
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