Plazemska obdelava umetnih žil (Slovene)

The original results on modification of substrates for selective adsorption of cells open a new approach to understanding complex mechanisms involved in interaction between different cells and polymer materials. This is currently a hot topic due to increasing rate of cardiovascular diseases in modern societies. While numerous studies have been performed worldwide, the phenomena are still far from being well understood. Our contribution represents a small fragment but the originality of our approach is promising to explain at least some observations and indicate possible solutions in preventing adsorption of proteins on vascular grafts. The results may lead to development of methods for minimization of platelets activation on vascular grafts thus minimizing the risks of thrombosis. An important scientific impact is detailed study of interaction between blood proteins and surfaces of PET materials since there no a generally accepted theory is available. A handful of hypotheses have been proposed and the list includes our own published recently in respected specialized journal Macromolecular Bioscience (see scientific achievement #4). A key scientific result is also the first report worldwide on the reasons for ageing plasma treated materials which reflects in the loss of hemo-compatibility over a period of time. Detailed description and possible explanations for the ageing effects have been revealed in our paper published in a top journal in the field of surface engineering (see achievement #1). Worldwide recognition of our results is reflected also in a number of invited lectures given by members of the research team. A selection is given under socio-economic results.

To the best of our knowledge there are not many groups in Slovenia performing research that leads to development of new products or services for biomedical applications. Such products and services are characterized by high value added. The activities within this project enhance research in this field which is a priority in highest developed countries worldwide. These activities enable Slovenian partners to compete with groups in highest developed countries and open a niche which is characterized by extremely high value added.