Moderate and high cancer risk population:counseling, mutational screening and prevention strategies

The expected results of the program will be scientifically important because we will be discovering specific mutation in Slovene population and the specific mutations pattern in Slovene population. These results can only be acquired by the study of our population; results however will be also internationally interesting. Furthermore, work with low penetrance genes in moderately elevated cancer risk families is also expected to be scientifically interesting. During the program specific tests for most common mutation in our population will be discovered. International cooperation will also be intensified.

The expected results of the research program will be of high importance for Slovenia for various reasons: it will enable the evolution and establishment of the genetic counseling for the most common genetic cancers, the laboratory infrastructure for genetic testing, development of the national registry of the mutation carriers, development of the specific algorithms of prevention methods of families at risk. Taken together it will enable us better care for families and individuals at risk and more rational use of health professionals and equipment. During program we intend to additionally analyze the data fro the mammographic screening program in order to study women at moderate breast cancer risk. The program, which is based on cooperation of several institutions, will be of high importance for the education of devoted health professionals. Particularly important is the cooperation with the University clinical center Maribor for the evolution of genetic counseling. It will also add to the international cooperation of Slovenia.