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Projects / Programmes
Cross-talk between cell cycle regulation and cholesterol & drug metabolism in the mammalian liver
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 1.05.00 | Natural sciences and mathematics | Biochemistry and molecular biology |
| Code | Science | Field |
|---|---|---|
| P004 | Natural sciences and mathematics | Biochemistry, Metabolism |
| B200 | Biomedical sciences | Cytology, oncology, cancerology |
| P320 | Natural sciences and mathematics | Nucleic acids, protein synthesis |
| P340 | Natural sciences and mathematics | Lipids, steroids, membranes |
Keywords
cell cycle, apoptosis, liver cancer, cholesterol homeostasis, xenobiotic metabolism
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (1) , Researchers (2)
0381 University of Ljubljana, Faculty of Medicine
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 20347 | Veterinarian medicine | Researcher | 2005 - 2007 | 133 | |
| 2. | 06135 | Biochemistry and molecular biology | Head | 2005 - 2007 | 1,071 |
Abstract
With the proposed project we endeavor exploit the cross-talk between cell cycle regulation and cholesterol homeostasis and drug metabolism in liver. Humans are exposed to broad spectrum of xenobiotics that activate nuclear receptors. Their chronic activation can lead to liver tumorigenesis. Disrupted cholesterol homeostasis is one of the malignant transformation of cancer cells. We will investigate cholesterol biosynthesis in different stages of cell cycle as well as the impact of nuclear receptor activation on hepatocyte cell cycle and apoptosis regulation.