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Projects / Programmes
T lymphocytes, immune complexes and leukotrienes in patogenesis of chronic urticaria
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 3.01.00 | Medical sciences | Microbiology and immunology |
| Code | Science | Field |
|---|---|---|
| B500 | Biomedical sciences | Immunology, serology, transplantation |
Keywords
chronic urticaria, T lymphocytes, immune deposites, leukotrienes
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (1) , Researchers (3)
1613 University Clinic of Respiratory and Allergic Diseases
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 15781 | Oncology | Researcher | 2002 - 2004 | 604 | |
| 2. | 10921 | Microbiology and immunology | Head | 2002 - 2004 | 1,657 | |
| 3. | 00288 | Microbiology and immunology | Researcher | 2002 - 2004 | 489 |
Abstract
Chronic urticaria is an unpleasant diseases which is not accesible for ethiologic treatment. According to prominent mast cell and eosinophil infiltrate a prominent role of sulphidoleukotriens in the pathogenesis of chronic urticaria is expected and a role of antileukotriene drugs might become impotrant. 30 adult patients with chronic urticaria and poor response to systemicantihistamines would be additionally double blind crossover treated with antileukotriene montelucast 10 mg. The area of involved skin and itching would be followed. Activation of lymphocyte subpopulation, their cytokine profile, appearance and characteristics of immune deposites will be studied in 3 mm skin punch biopsies.