There is a substantial differentiation in terms of R&I performance among the EU member states. This divide has also been reflected in differing levels of participation in the framework programmes, for which the allocation of funding is based on excellence. Considering these facts, TWIN SYNERGIES project aims at supporting the EU strategic context in regard to creation of synergies at the operational and governance level, directing towards the Upstream synergies mode – Human resources development and Internationalisation. TWIN SYNERGIES project, gathering 9 partners from 4 Widening countries and 1 EU Member State will in 24-month project duration develop and apply upstream compatible, tailor-made, but transferable activities for capacity building, internationalisation, HR development, collaboration, valorisation, and technology uptake, focusing on the current developments related to the Green and Digital transition.