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Projects / Programmes
Optimization of MDP and TNF analogues having therapeutic potential
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 1.09.00 | Natural sciences and mathematics | Pharmacy |
| Code | Science | Field |
|---|---|---|
| B470 | Biomedical sciences | Physiology |
| B500 | Biomedical sciences | Immunology, serology, transplantation |
Keywords
Analogues, TNF-alpha, MDP, antitumor activity, immunomodulators, immunorestoration, immunosuppression, drugs
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (5) , Researchers (26)
0104 National Institute of Chemistry
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 06108 | Biotechnology | Researcher | 1998 - 2000 | 226 | |
| 2. | 17275 | Researcher | 1998 - 2000 | 0 | ||
| 3. | 00385 | Biotechnology | Researcher | 1998 - 2000 | 227 | |
| 4. | 17276 | Researcher | 1998 - 2000 | 2 |
0258 Lek Pharmaceutical Company d.d.
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 04652 | Chemistry | Researcher | 1998 - 2000 | 101 | |
| 2. | 16171 | Biotechnology | Researcher | 1998 - 2000 | 51 | |
| 3. | 07822 | Pharmacy | Researcher | 1998 - 2000 | 6 | |
| 4. | 12942 | Pharmacy | Researcher | 1998 - 2000 | 241 | |
| 5. | 09924 | Pharmacy | Researcher | 1998 - 2000 | 57 | |
| 6. | 01494 | Biotechnology | Researcher | 1998 - 2000 | 167 | |
| 7. | 00830 | Biotechnology | Head | 1998 - 2000 | 164 | |
| 8. | 09963 | Pharmacy | Researcher | 1998 - 2000 | 0 | |
| 9. | 04651 | Chemistry | Researcher | 1998 - 2000 | 14 |
0302 Institute of Oncology Ljubljana
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 03286 | Oncology | Researcher | 1998 - 2000 | 1 | |
| 2. | 08007 | Oncology | Researcher | 1998 - 2000 | 518 | |
| 3. | 08800 | Oncology | Researcher | 1998 - 2000 | 1,598 |
0311 Blood Transfusion Centre of Slovenia
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 01302 | Biotechnology | Researcher | 1998 - 2000 | 386 | |
| 2. | 10453 | Microbiology and immunology | Researcher | 1998 - 2000 | 136 |
0787 University of Ljubljana, Faculty of Pharmacy
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 15284 | Pharmacy | Researcher | 1998 - 2000 | 899 | |
| 2. | 01463 | Pharmacy | Researcher | 1998 - 2000 | 580 | |
| 3. | 00839 | Pharmacy | Researcher | 1998 - 2000 | 351 | |
| 4. | 17437 | Researcher | 1998 - 2000 | 0 | ||
| 5. | 03070 | Pharmacy | Researcher | 1998 - 2000 | 427 | |
| 6. | 08519 | Pharmacy | Researcher | 1998 - 2000 | 689 | |
| 7. | 01878 | Pharmacy | Researcher | 1998 - 2000 | 387 | |
| 8. | 17438 | Researcher | 1998 - 2000 | 0 |
Abstract
On the basis of the previous projects about 100 desmuramyl analogues of muramyl dipeptide have been synthesized and evaluated; two analogues have a potential for the therapy of immunological diseases. The present project is directed to those technological and medical studies of two analogues which could contribute to the development of the final drug. On the other handžwe discovered, during development of tumor necrosis factor (TNF) analogues, a region on its molecule where replacement of certain amino acid residues can lead to new molecules having improved activity with reduced systemic toxicity. New TNF analogues will be developed and tested for their anti-tumor activity.