Loading...
Projects / Programmes
Nivo stefinov A in B, katepsina S in kreatinina v bioloških tekočinah zdravih oseb in bolnikov z astmo (Slovene)
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 3.01.00 | Medical sciences | Microbiology and immunology |
| Code | Science | Field |
|---|---|---|
| B540 | Biomedical sciences | Respiratory system |
| B190 | Biomedical sciences | Clinical chemistry |
Keywords
stefin A, stefin B, cathepsin S, creatinine, circadian variations, asthma
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (2) , Researchers (9)
0259 Krka, tovarna zdravil, d.d., Novo mesto (Slovene)
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 10291 | Pharmacy | Researcher | 2000 - 2002 | 120 | |
| 2. | 04648 | Biotechnical sciences | Researcher | 2000 - 2002 | 1,221 | |
| 3. | 06394 | Pharmacy | Researcher | 2000 - 2002 | 91 |
1613 University Clinic of Respiratory and Allergic Diseases
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 15710 | Cardiovascular system | Researcher | 2000 - 2002 | 564 | |
| 2. | 15781 | Oncology | Researcher | 2000 - 2002 | 604 | |
| 3. | 10921 | Microbiology and immunology | Researcher | 2000 - 2002 | 1,657 | |
| 4. | 06630 | Biochemistry and molecular biology | Head | 2000 - 2002 | 362 | |
| 5. | 09808 | Cardiovascular system | Researcher | 2000 - 2002 | 357 | |
| 6. | 06779 | Microbiology and immunology | Researcher | 2000 - 2002 | 416 |
Abstract
The objective is to determine levels of stefins A and B, cathepsin S and creatinine in biological fluids of healthy and asthmatic subjects. The purpose is to characterise their circadian rhythms in serum in order to evaluate the influance of daily variations on the sampling, and to determine their deviations before and after corticosteroid and cyclosporine A treatment. In order to evaluate potential of cystatin C as a marker of glomerular filtration rate in asthmatic patients creatinine levels will be measured in the same samples. The results may provide better understanding of the role of cysteine proteinases and their inhibitors in pathophysiological processes of asthma and may be of clinical interest as additional biochemical parameters for monitoring the disease and its therapy.