Interakcija genski dejavniki - okolje in srcni infarkt pri zenskah (Slovene)

Myocardial infarction (MI) is the major cause of death among postmenopausal women in many industrialized countries. As was shown in the Framingham Heart Study, women were more likely to die after MI than men and they have worse prognosis. In the evolution of multufactorial disorder-MI the processes of atherogenesis and trombosis are involved. Hormonal status in women, which changes in menopause, interacts with known risk factors such as hypercholesterolemia, smoking, arterial hypertension, genotype DD of angiotensin-convering enzyme 1, and the consequence is MI. We will focus on gene variability of renin-angiotensin system, apolipoprotein E, plasminogen activator inhibitor 1 and factor V point mutation. In association study, at least 100 women with MI will be analyzed. We will focus on gene variability of estrogen, components of renin-angiotensin system, apolipoprotein E, plasminogen activator inhibitor 1 and factor V point mutation. Addiotionally, we will study the interaction on the MI risk between genotypes of tested polymorphisms and environmental risk factors for MI in women younger than 65 years.