Projects / Programmes

Organisations (2) , Researchers (7)

0104  National Institute of Chemistry

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	06628	PhD Roman Jerala	Biochemistry and molecular biology	Head	1999 - 2001	1,267
2.	12060	PhD Primož Pristovšek	Chemistry	Researcher	2000 - 2001	135
3.	01661	PhD Tomaž Šolmajer	Chemistry	Researcher	2000 - 2001	380

0259  Krka, tovarna zdravil, d.d., Novo mesto (Slovene)

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	15776	MSc Mojca Golob	Pharmacy	Researcher	1999 - 2001	14
2.	04648	PhD Janko Kos	Biotechnical sciences	Researcher	1999 - 2001	1,221
3.	07084	PhD Andreja Plaper	Pharmacy	Researcher	2000 - 2001	37
4.	07344	Stanislav Zalar	Pharmacy	Researcher	1999 - 2001	14

Abstract

Purpose of the project is to establish a full circle of a development of novel antimicrobial drugs - gyrase inhibitors. The project will integrate biotechnological techniques of cloning and isolation of recombinant bacterial gyrases, computational design of novel drugs based on the tertiary structure of the enzyme, organic synthesis of novel compounds, in vivo and in vitro testing of their inhibition of the gyrase and determination of tertiary structure of complexes by X-ray crystallography and NMR. Goal of the project is the synthesis of a novel gyrase inhibitor based on the rational drug design.