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Projects / Programmes
Role of lanosterol 14alpha- demethylase in biosynthesis of cholesterol and strols with signalling properties
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 1.05.00 | Natural sciences and mathematics | Biochemistry and molecular biology |
| Code | Science | Field |
|---|---|---|
| P004 | Natural sciences and mathematics | Biochemistry, Metabolism |
| P320 | Natural sciences and mathematics | Nucleic acids, protein synthesis |
Keywords
lanosterol 14alpha-demethylase,cytochrome P450, cholesterol, MAS sterols, spermatogenesis
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (2) , Researchers (4)
0381 University of Ljubljana, Faculty of Medicine
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 18992 | Biochemistry and molecular biology | Researcher | 1999 - 2001 | 129 | |
| 2. | 06135 | Biochemistry and molecular biology | Researcher | 1999 - 2001 | 1,071 | |
| 3. | 06013 | Biochemistry and molecular biology | Head | 1999 - 2001 | 940 |
0406 University of Ljubljana, Veterinary Faculty
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 01043 | Veterinarian medicine | Researcher | 1999 - 2001 | 74 |
Abstract
The tissue-specific mechanisms of expression of mammalian CYP51 in liver as the main cholesterogenic organ and testis which show the highest level of CYP51 expression will be studied. The hypothesis that the tissue-specific regulatin of CYP51results in its dual function (cholesterol biosynthesis and synthesis of sterols with signalling properties) will be evalueted. Mouse CYP51 gene will be cloned and CYP51-loxP construct for conditional knockout with the Cre-loxPtechnology prepared. The role of CYP51in spermatogenesis in pig as a large model mammal will be studied.