Analysis of late sequelae of cancer treatment in childhood

The results of treatment of malignant diseases in children have dramatically improved during the last decades, from about 10% to about 75% overall survival. Studies of late sequelae of treatment for childhood cancer are at present the major concern of pediatric oncology. The aim of the study is to identify groups of patients at risk for late sequelae, to define their causes (genetic damage) and analyze other variables, such as radiation and cytotoxic drugs, known for their toxic effects. The aims of the project are to find the somatic and psychological late sequelae of cancer treatment in childhood; to analyze their correlation with such clinical factors as patient''s age, mode of treatment, diagnosis, etc. The following is possible on the basis of the findings: a) prevent these sequelae with treatment modifications of the children treated at present; b) treat late sequelae; c) incorporate the results of the study into the Medical School curriculum.