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Projects / Programmes
Genetska analiza nekaterih tumor supresor genov (Slovene)
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 3.04.00 | Medical sciences | Oncology |
| Code | Science | Field |
|---|---|---|
| B007 | Biomedical sciences | Medicine (human and vertebrates) |
| B200 | Biomedical sciences | Cytology, oncology, cancerology |
Keywords
tumor suppressor genes, oncogenes, genetic analysis, hereditary cancer, hereditary colorectal cancer, HNPCC, FAP, von Hippel-Lindau syndrome, multiple endocrine neoplasya, MEN 2, MEN 1, cancerogenesis, Slovenian population
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (3) , Researchers (9)
0381 University of Ljubljana, Faculty of Medicine
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 09275 | Chemistry | Researcher | 1998 - 2001 | 572 | |
| 2. | 18361 | Researcher | 1998 - 2001 | 5 | ||
| 3. | 07187 | Oncology | Researcher | 1998 - 2001 | 134 | |
| 4. | 07228 | Oncology | Researcher | 1998 - 2001 | 78 | |
| 5. | 01502 | Biochemistry and molecular biology | Head | 1998 - 2001 | 281 |
0302 Institute of Oncology Ljubljana
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 02686 | Oncology | Researcher | 1998 - 2001 | 365 |
0312 University Medical Centre Ljubljana
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 13549 | Metabolic and hormonal disorders | Researcher | 1998 - 2001 | 109 | |
| 2. | 01546 | Medical sciences | Researcher | 1998 - 2001 | 144 | |
| 3. | 18539 | Researcher | 1996 - 2001 | 0 |
Abstract
Genes most frequently connected with hereditary predisposition for cancer are tumor suppressor genes. Known genes (MSH2, MLH1, APC, PT53, VHL, RET) connected with hereditary colorectal cancer, von Hippel-Lindau syndrome, multiple endocrine neoplasya have been studied in Slovenian population. In addition mapping of possible new genes connected with defined pathology is under consideration. PCR-Conformational analysis, detection of LOH and linkage analysis have been used. Results of genetic study will represent a basis for population analysis and a contribution to understanding genetic mechanisms of cancer. The detection of mutation in a given family with hereditary cancer syndrome means also the possibility for presymptomatic genetic testing of family members at risk and thus early detection and prevention of the disease.