Equipment source: ARIS

Nanomanipulator of individual molecules based on TIRF and optical tweezer

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Purpose of equipment
The LUMICKS C-Trap EDGE 350 allows simultaneous TIRF measurements in three channels (488nm, 532nm and 638nm), imaging of fibres or other structures on the glass surface without labels (IRM - Interference Reflection Microscopy), and the use of optical tweezers for sample manipulation and force measurements. The instrument is coupled to a 6 channel microfluidic system. The single-molecule nanomanipulator thus combines three optical methods to detect molecules and particle movements with an accuracy of up to 1 nanometre.
Access of equipment
Responsible for equipment: PhD Martina Mohorčič
Upon agreement with the administrator dr. Ajasja Ljubetič (ajasja,ljubetic@ki.si)
Research projects (2) Legend
no. Code Title Period Head No. of publications
1.  N1-0323  Random walker built from coiled-coils and de-novo proteins  10/1/2023 - 9/30/2025  PhD Ajasja Ljubetič  133 
2.  J1-4406  CC-Trigger: toehold mediated protein coiled-coil displacement to introduce kinetic control of protein assemblies and advanced multi-state devices.  10/1/2022 - 9/30/2025  PhD Ajasja Ljubetič  1,736 
ARIS research and infrastructure programmes (1) Legend
no. Code Title Period Head No. of publications
1.  P4-0176  Synthetic biology and immunology  1/1/2022 - 12/31/2027  PhD Roman Jerala  2,530 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  22,763 
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